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. 2017 Oct 16;1(23):2019–2031. doi: 10.1182/bloodadvances.2017010181

Figure 4.

Figure 4.

Frequency of regulatory T cells in spleen and lymph nodes. (A-B) Male C57BL/6 mice (n = 5) injected with 1 × 109 vg of exo- or standard AAV8-hF.IX and euthanized 2 weeks later. (A) Representative flow cytometry plot showing the frequency of CD25+FoxP3+ Tregs gated on CD3+CD4+ T cells. (B) Frequency of Tregs in spleens and inguinal lymph nodes. (C-D) Analysis of frequency of Tregs in male C57BL/6 mice (n = 5 per group) treated with 1 × 109 vg of exo- or standard AAV5-hF.IX and euthanized 28 days later. Data are shown as mean ± SEM. *P < .05, **P < .01; Mann-Whitney U test.