Table 4.

Neurologic abnormalities at presentation and after PEX began in 78 patients with their initial episode of TTP

	Number of patients with neurologic abnormalities
Neurologic abnormalities	At presentation		After PEX began		Total neurologic abnormalities
	No.	%	No.	%	No.	%
None	26	33	60	77	16	20
Minor	20	26	2	3	21	27
Severe	32	41	16	20	41	53
Coma	2	3	4	5	6	8
Stroke	6	8	4	5	9	12
Seizure	6	8	7	9	12	15
Transient focal abnormalities	26	35	10	10	31	40

Minor neurologic abnormalities were not recorded in patients who had severe neurologic abnormalities. Neurologic abnormalities documented after PEX began were distinct abnormalities. One patient had a recurrent minor abnormality after PEX began. Seven patients had distinct severe abnormalities both at presentation and after PEX began. Among the 4 categories of severe abnormalities, 17 of the 41 patients had abnormalities in multiple categories. One patient had an extension of her stroke after PEX began; 12 had seizures; 1 had seizures before PEX began and another seizure after her initial PEX; 31 had transient focal neurologic abnormalities; 5 had recurrent abnormalities (diplopia, aphasia, face/hand weakness/numbness) after PEX began; 19 had transient focal abnormalities as their only severe abnormality; and 12 had transient focal abnormalities in addition to seizures, stroke, and/or coma.