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. 2017 Nov 2;45(22):12808–12815. doi: 10.1093/nar/gkx1009

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — rGMP replaces rAMP as the predominant embedded ribonucleotide in mtDNA in the liver of the Mpv17 knockout mouse. (A) Alkali (NaOH) fragmentation of liver mtDNA from wild-type (WT) and Mpv17 knockout (KO) mice analyzed by agarose gel electrophoresis and Southern hybridization with probes to np 4000–8120 (probe a) and 14881–16299 (probe b); MBN – mung bean nuclease treatment. (B) The proportion and (C) the distribution (enlarged in Supplementary Figures S4 and S8) of the rNMPs in murine liver mtDNA with (WT) or lacking (KO) the Mpv17 gene.