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. 2017 Nov 23;45(22):e184. doi: 10.1093/nar/gkx1194

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Capture-C in samples fixed with varying formaldehyde concentrations shows that detection of chromatin interactions does not depend on the degree of crosslinking. (A) Comparison of NG Capture-C interaction profiles generated from the viewpoint of the α-globin promoters in primary erythroid cells that have been fixed with different concentrations of formaldehyde. Profiles show the mean number of unique interactions per restriction fragment from technical duplicates, normalized for a total of 100 000 interactions genome-wide, with the scales adjusted for the different conditions. (B) Percentage of unique interactions detected in cis in samples fixed with varying formaldehyde concentrations. Percentages represent an average of two technical replicates. (C) Digestion efficiencies in 3C libraries generated from samples fixed with varying formaldehyde concentrations. Graph represents the mean and standard error of two technical replicates.