Table 3.

Estimates of the fraction of the cell line mixtures while assuming different number of tumor clones (K). BIC = −2l + (2SK + K)log(N). All the proportions are shown in percentages. The selected models based on BIC values are highlighted in bold for each sample. Here l is the log likelihood function, S is the number of segments and N is the total number of observations.

True prop.		Estimated prop.
		K = 1			K = 2				K = 3
Normal	Tumor	α0	α1	BIC	α0	α1	α2	BIC	α0	α1	α2	α3	BIC
0	100	5	95	6960	2	21	77	6878	2	7	25	66	10329
21	79	22	78	9456	19	17	64	9251	10	6	10	74	12477
50	50	61	39	7317	57	9	34	8635	49	7	10	34	12183
53	47	59	41	7524	55	8	37	9155	45	4	11	40	12584
55	45	70	30	6679	59	12	29	8456	64	3	5	28	11823
66	34	71	29	5938	68	8	24	7177	63	3	5	29	10088
70	30	75	25	5940	72	7	21	7471	66	3	5	26	10586
77	23	73	27	5750	66	5	29	7713	64	3	5	28	10925
79	21	83	17	4161	81	4	15	5314	76	3	4	17	7489
86	14	93	7	3074	89	3	8	4402	85	2	3	10	6229
90	10	94	6	2005	91	3	6	2846	74	5	6	15	4061