Table 1. Effects of nicotine and obesity on metabolic parameters.
| NFD | Nic | HFD | HFD/nic | |
|---|---|---|---|---|
| HW (g/100 g BW) | 0.31 ± 0.01 | 0.31 ±0.01 | 0.3 ± 0.01 | 0.3 ± 0.01 |
| AW (mg/cm) | 17.4 ± 0.5 | 17.0 ± 0.5† | 18.7 ± 0.4* | 18.6 ±0.7* |
|
Plasma glucose (mg/dl) |
112 ± 5 | 113 ± 4† | 125 ± 2* | 124 ± 3* |
|
Plasma insulin (ng/ml) |
3.3 ±0.2 | 3.4 ± 0.2† | 3.8 ±0.1* | 3.8 ± 0.1 |
|
Plasma cotinine (ng/ml) |
undetectable | 5.8 ± 1.6 | Undetectable | 9.1 ± 2.8 |
|
Plasma cholesterol (mg/dl) |
83 ± 5 | 79 ± 3† | 112 ± 4* | 106 ± 7* |
| NFFA (mmol/L) | 0.60 ± 0.04 | 0.68 ±0.1† | 1.07 ±0.21* | 0.99 ±0.06* |
| HOMA-IR | 24.6 ± 1.4 | 25.6 ± 1.1† | 31.7 ± 1.3* | 31.4 ± 1.5* |
NFD: low fat diet; HFD: high fat diet; Nic: nicotine; HW: heart weight; AW: aortic weight; BW: body weight; NFFA: noesterified free fatty acids. Data was expressed as mean ± SE,
*p<0.05, vs. NFD;
†p<0.05, vs. HFD. N = 5–6.