Table 2. mRNA profile of inflammatory cytokines in the aorta of nicotine-treated obese rats (data was normalized by NFD group as 1, determined by PCR array).
| NFD | Nic | HFD | HFD/Nic | |
|---|---|---|---|---|
| CCL2 (MCP1) | 1 ± 0.13 | 1.03 ± 0.12 | 2.13 ± 0.25* | 2.01 ± 0.26* |
| MIF | 1 ± 0.15 | 0.97 ± 0.20 | 1.21 ± 0.42 | 3.01 ±0.75*# |
| CXCL9 | 1 ± 0.25 | 0.92 ± 0.22 | 1.25 ± 0.45 | 5.54 ± 1.25*# |
| CXCL10 | 1 ± 0.35 | 0.77 ± 0.28 | 1.34 ± 0.25 | 2.76 ±0.80*# |
| CXCL11 | 1 ± 0.23 | 0.85 ± 0.15 | 2.79 ± 0.55* | 7.51 ± 1.32*# |
| CXCr 3 | 1 ± 0.18 | 0.73 ± 0.22 | 0.83 ± 0.30 | 3.26 ± 1.12*# |
| Interferon γ | 1 ± 0.20 | 0.92 ± 0.35 | 3.92 ± 1.02* | 9.82 ± 2.15*# |
| IL4 | 1 ± 0.22 | 1.09 ± 0.16 | 1.35 ± 0.50 | 3.63 ± 0.65*# |
| IL6 | 1 ± 0.10 | 1.21 ± 0.15 | 1.25 ± 0.22 | 5.45 ± 0.72*# |
| TNFα | 1 ± 0.35 | 1.39 ± 0.37 | 3.52 ± 0.65* | 5.25 ± 0.86*# |
| CD40 ligands | 1 ± 0.12 | 1.13 ± 0.22 | 1.45 ± 0.33 | 3.43 ± 0.98*# |
Nic: nicotine, MCP-1: monocyte chemoattract protein 1, MIF: macrophage migration inhibitor factor, TNFα: tumor necrosis factor α, IL: interleukin. Data was normalized and expressed as fold increase by lean group. Data was expressed as mean ± SE, 4 PCR array for each group.
*p<0.05 vs. NFD,
#p<0.05 vs. HFD.