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. 2017 Jun 29;1(16):1224–1237. doi: 10.1182/bloodadvances.2017005249

Figure 4.

Figure 4.

Representative structure of the protein Z–dependent protease inhibitor (SERPINA10) showing the 3-dimensional orientation of residue Q384 (in red) and the reactive center loop (RCL, in pink). The protein model was created using PyMOL (PDB codes: 3H5C for native and 4AFX for RCL-inserted forms). (A) The native protein. (B) Binding of a target protease to the RCL results in cleavage and insertion of the RCL into the central β-sheet.