Table 3.

Competing risk analysis univariate 10-year cumulative incidence rates and multivariable hazard ratios for contralateral breast cancer and ipsilateral recurrence by characteristics at initial diagnosis of DCIS

	Competing risk cumulative incidence rates (univariate analysis)				Competing risk regression hazard ratios (multivariable analysis)
	10-yr CBC risk	p- value*	10-yr IBTR risk	p- value**	CBCHR	p- value	IBTR HR	p- value
Age, yrs
≤49	6.1%	0.9	17.6%	0.002	ref	0.72	ref	0.002
≥50	5.6%		13.2%		0.93		0.68
Family history
No	5.4%	0.3	14.0%	0.47	ref	0.7	ref	0.54
Yes	6.2%		15.1%		1.08		1.08
Presentation
Radiologic	6.3%	0.01	13.6%	0.001	ref	0.06	ref	0.013
Clinical	2.3%		20.1%		0.47		1.49
Nuclear grade
Low	5.2%	0.4	12.7%	0.1	ref	0.49	ref	0.002
Intermediate/high	6.2%		14.5%		1.21		1.65
Year of surgery
≤1998	4.1%	0.09	19.3%	< 0.0001	ref	0.1	ref	0.037
≥1999	6.6%		13.2%		1.45		0.75
Radiation
No	5.2%	0.2	19.5%	< 0.0001	ref	0.82	ref	<0.0001
Yes	6.3%		10.4%		1.05		0.46
Endocrine therapy
No	6.5%	0.2	16.5%	< 0.0001	ref	0.07	ref	0.004
Yes	3.2%		7.8%		0.61		0.59

^*p-value for each co-variate for risk of CBC; calculated using Gray’s test

^**p-value for each co-variate for risk of IBTR; calculated using Gray’s test

HR = hazard ratio

IBTR = ipsilateral breast tumor recurrence

CBC = contralateral breast cancer