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. Author manuscript; available in PMC: 2018 Oct 15.
Published in final edited form as: Arch Biochem Biophys. 2017 Aug 15;632:11–19. doi: 10.1016/j.abb.2017.08.011

Fig. 1.

Fig. 1

Thymidylate synthase structures. (A) Classical Thymidylate Synthase (TSase) is a homodimer with two identical active sites each binding dUMP and CH2H4folate. (B) Flavin-Dependent Thymidylate Synthase (FDTS) is a homotetramer with four identical active sites each binding dUMP, CH2H4folate, and FAD with possible allosteric sites for CH2H4folate. Each subunit is colored differently and ligand coloring is as follows: His53 (green), folate (yellow), FAD (cyan), and dUMP (magenta). PDB codes are 2KCE (TSase) and 4GT9 (FDTS).