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. Author manuscript; available in PMC: 2018 Oct 15.
Published in final edited form as: Arch Biochem Biophys. 2017 Aug 15;632:11–19. doi: 10.1016/j.abb.2017.08.011

Fig. 2.

Fig. 2

Active site view of TmFDTS-dUMP-FAD-folate complex. The folate derivative is folinic acid, an analogue of the reactive form of CH2H4folate. The carbonyl oxygen of folinic acid has been omitted for clarity. (A) Folinic acid and FAD modeled in opposite locations with His53 rotated and C2′–C3′ and C1′-N10 of FAD rotated to allow for binding. (B) Crystallographic structure of FDTS active site with known reactive locations of all substrates and the FAD binding motif shown as a red ribbon. Color scheme is the same as Fig. 1. PDB code is 4GTA. Figure 2A reproduced with permission from Ref. [17].