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. Author manuscript; available in PMC: 2019 Feb 15.
Published in final edited form as: Biol Psychiatry. 2017 Jun 13;83(4):369–376. doi: 10.1016/j.biopsych.2017.06.004

Figure 1. Aβ oligomers (Aβo) bind Cellular Prion Protein (PrPC) to activate Fyn kinase at Tyr416.

Figure 1

Extracellular binding initiates a pathologic intracellular signaling cascade, leading to acute changes in NMDA receptor trafficking, and persistent activation of Pyk2 and eEF2. Fyn plays a central role in the proposed signaling cascade, and can be inhibited in vivo by the orally available Src family kinase inhibitor saracatinib.