Skip to main content
. Author manuscript; available in PMC: 2017 Dec 14.
Published in final edited form as: Mol Psychiatry. 2017 Jun 13;23(3):621–628. doi: 10.1038/mp.2017.112

Figure 4.

Figure 4

Human PSD3 phenotypes. (Top) Associations of PSD3 with frequency of drinking (IMAGEN), alcohol dependence (SAGE Caucasian) and BOLD response during Go/No-Go task (IMAGEN), a measure of executive control. The minor G allele of SNP rs13265422 is associated with increased frequency of drinking in the last 30 days in the IMAGEN cohort of 16-year old European adolescents (GG-genotype average score = 1.77, n = 146; GT-genotype average score = 1.49 n = 620; TT-genotype average score = 1.34, n = 597). The haplotype phase 7 shows association not only with increased frequency of drinking in the last 30 days (IMAGEN), but also shows association with increased alcohol dependence in an independent sample of Caucasian adults (SAGE), as well as increased activation contrast between ‘No-Go success vs. Go success’ in the right inferior frontal gyrus (IMAGEN). Gender and sites were controlled for all analyses where applicable, and handedness was controlled for fMRI phenotypes. (Bottom) Illustration of right inferior frontal gyrus (rIFG) activation as red area in coronal view. The slides were acquired based on MNI sagittal coordinates 8, 18, 28, 38, 48 (from left to right).