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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Neurosci Biobehav Rev. 2017 Aug 30;84:289–298. doi: 10.1016/j.neubiorev.2017.08.018

TABLE 1.

Contrast in the effects of depression and nicotinic acetylcholine receptor agonists on intrinsic functional network activity

Activity in Depression Effect of nAChR agonists
Default Mode Network (DMN) ↑ Activity ↓ Activity
Central-Executive Network (CEN) ↓ Activity ↑ Activity
Salience Network (SN) ↑ Activity ↓ Activity (Anterior insula)

The table describes a summary of activity of brain regions within each network across tasks and does not reflect resting state functional connectivity. Note that there are less data on the effects of nAChR agonists on salience network activity. Although a meta-analysis reported that nAChR agonists decrease activity in the anterior insula,(Sutherland et al., 2015) they did not find evidence for an effect on other SN regions such as the amygdala.