Table 2.
Outcome | No Antipsychotic Exposure n (%) (n = 136,153) |
Antipsychotic Exposure n (%) (n = 10,399) |
Unadjusted Odds Ratio [95% CI] (n = 146,552) |
Adjusted Odds Ratioa [95% CI] (n = 146,552) |
Propensity Matched Odds Ratiob [95% CI] (n = 20,406) |
---|---|---|---|---|---|
Aspiration pneumonia | 430 (0.3) | 127 (1.2) | 3.9 [3.2–4.8] | 1.5 [1.2–1.9] | 1.4 [1.1–1.8] |
Non-aspiration pneumonia | 956 (0.7) | 175 (1.7) | 2.4 [2.1–2.9] | 1.1 [0.9–1.3] | 1.0 [0.8–1.2] |
Adjusted for all variables listed in Table 1, plus the Healthcare Cost and Utilization Project comorbidities,24 using a multivariable GEE to take into account dependency of the data due to repeated hospitalizations.
Matched on propensity score and analyzed using a multivariable GEE, controlling for all significantly imbalanced baseline characteristics after matching, as demonstrated in Table 3 (using a standardized difference (absolute value) >0.1).