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. 2017 Sep 21;55(11):881–890. doi: 10.5414/CP203005

Table 3. Pharmacokinetic parameters of oxycodone after multiple-dose administration of OOD and OTD.

Parameter	Study 3 (multiple dose)
Parameter	OOD	OTD
AUC_ss(0–24h) (ng/mL×h)^a	111.54 [116.22] (65.81 – 206.29)	98.05 [103.63] (54.45 – 228.06)
C_{max,ss(0–24h)} (ng/mL)^a	6.76 [7.05] (4.43 – 13.73)	6.97 [7.42] (4.03 – 20.64)
C_τ,ss,24h (ng/mL)^a	2.57 [2.77] (0.57 – 6.02)	2.39 [2.57] (1.29 – 5.96)
HVD_ss(0–24h) (h)^b	18.9 ± 2.45 (11.0 – 23.2)	15.0 ± 3.37 (7.9 – 22.3)
PTF_ss(0–24h) (%) ^a	95.60 [97.13] (71.43 – 168.85)	116.41 [117.76] (77.69 – 188.84)

^aGeometric mean [arithmetic mean] (range); ^barithmetic mean ± standard deviation (range). OOD = oxycodone one daily; OTD = oxycodone twice daily.