Table 2.
Characteristics of included studies
| First author and year | study design | diagnosis | Operation | sample size | intervention /comparator | Follow-up duration, day |
|---|---|---|---|---|---|---|
| Varkarakis IM, et al.2005 [10] | Retrospective | Atrial fibrillation Mechanical heart valve Venous thromboembolism Other (not specified) | abdominal surgery | B:25 NB:762 |
B:LMWH and UFH NB: non-VKA |
30 |
| Marquie C, et al.2006 [11] | Retrospective | Atrial fibrillation Mechanical heart valve | Cardiac device implantation | B:114 NB:114 |
B:LMWH and UFH NB: non-VKA |
30 |
| Wysokinski WE, et al.2008 [12] | Prospective | NVAF | Outpatient dental procedures, Cataract surgery, Other minor outpatient procedures, Open-heart surgery, abdominal vascular surgery, Neurosurgery, Major cancer surgery, Urologic procedures | B:204 NB:182 |
B:LMWH NB: interrupt warfarin |
30 |
| Garcia DA, et al.2008 [13] | Prospective | Atrial fibrillation Mechanical heart valve Stroke Left ventricular dysfunction Other (not specified) | Biopsy Dental procedures, Dermatological procedures, Endoscopy Neurological procedures, Ophthalmological surgery, Urologic surgery | B:108 NB:1185 |
B:LMWH and UFH NB: continue warfarin |
30 |
| p.p.karjalainen, et al.2008 [14] | Retrospective | AF | PCI | B:78 NB:66 |
B:LMWH and UFH NB: continue warfarin |
30 |
| Daniels PR, et al.2009 [15] | Retrospective | MHV | Angiography Biopsies Cardiac procedures, Cardiothoracic surgery, Dental procedures, Endoscopy General surgery, Gynecologic surgery, Head and neck surgery, Miscellaneous procedures, (thoracentesis) Neurological procedures, Neurosurgery Ophthalmological surgery, Orthopedic surgery Urologic surgery, Vascular surgery | B:342 NB:213 |
B:LMWH and UFH NB: interrupt warfarin |
90 |
| Robinson M, et al.2009 [16] | Retrospective | Not specified | Cardiac device implantation | B:113 NB:35 |
B:LMWH NB: interrupt warfarin |
7 |
| Tischenko A, et al.2009 [17] | Prospective | Atrial fibrillation Prosthetic heart valve Venous thromboembolism Stroke/transient ischemic attack | Cardiac device implantation | B:38 NB:117 |
B:LMWH NB: continue warfarin & NOAC & non-VKA |
30 |
| Billett HH, et al.2010 [18] | Retrospective | AF | Not specified | B:265 NB:4532 |
B:LMWH NB: interrupt other OAC |
30 |
| Ercan M, et al.2010 [19] | Prospective | Atrial fibrillation & MHV& mitral heart valve& Mitral stenosis &Aortic stenosis &Peripheral vascular disease | laparoscopic cholecystectomy | B:44 NB:1421 |
B:LMWH NB: non-VKA |
30 |
| Ghanbari H, et al.2010 [20] | Retrospective | Atrial fibrillation Mechanical heart valve | Cardiac device implantation | B:29 NB:94 |
B:LMWH and UFH NB: interrupt & continue warfarin |
30 |
| Jaffer AK, et al.2010 [21] | Prospective | Atrial fibrillation Mechanical heart valve Venous thromboembolism Stroke with patent foramen ovale Cryptogenic stroke Antiphospholipid antibody with thrombosis Dilated cardiomyopathy Multiple indications (not specified) | abdominal surgery, Angiography Cardiothoracic surgery, Dental procedures, Dermatological procedures, Endoscopy, Head and neck surgery, Ophthalmological surgery Orthopedic surgery Vascular surgery | B:229 NB:263 |
B:LMWH and UFH NB: interrupt warfarin |
30 |
| McBane RD, et al.2010 [22] | Prospective | Venous thromboembolism | abdominal surgery, Cardiothoracic surgery Dental procedures General surgery Gynecologic surgery, Head and neck surgery, Interventional radiology Neurosurgery, Ophthalmological surgery, Orthopedic surgery Plastic surgery, Urologic surgery, Vascular surgery | B:514 NB:216 |
B:LMWH NB: interrupt warfarin |
90 |
| Tompkins C, et al.2010 [23] | Retrospective | Not specified | Cardiac device implantation | B:154 NB:559 |
B:LMWH and UFH NB: interrupt & continue warfarin &non-VKA |
42 |
| Smoyer-Tomic K, et al.2012 [24] | Retrospective | AF | Not specified | B:1944 NB:1093 |
B:LMWH and UFH NB: interrupt warfarin |
30 |
| Healey JS, et al.2012 [25] | Randomized trial | Not specified | pacemaker/defibrillator insertion, dental procedures, diagnostic procedures, cataract removal,colonoscopy, and joint replacement | B:1558 NB:3033 |
B:LMWH and UFH NB: NOAC |
30 |
| H. Lahtela, et al.2012 [26] | Prospective | AF | PCI | B:290 NB:161 |
B:LMWH and UFH NB: continue warfarin & NOAC |
30 |
| Birnie DH, et al.2013 [2] | Randomized trial | Not specified | Pacemaker or Defibrillator Surgery | B:338 NB:343 |
B:LMWH and UFH NB: continue warfarin |
14 |
| Schulman S, et al.2014 [27] | Randomized trial | AF& mechanical valve, bioprosthetic valve, cardiomyopathy, venous thromboembolism, Left ventricle thrombus | pacemaker or defibrillator implantation | B:85 NB:86 |
B:LMWH NB: interrupt warfarin |
30 |
| Beyer-Westendorf J, et al.2014 [28] | Prospective | SPAF,DVT,PE,OTHER | Superficial skin and oral mucosal surgery, including skin biopsies. Wound revisions. Non-extraction dental treatment. Transluminal cardiac, arterial, and venous interventions. Pacemaker-related surgery. Pleura and ascites puncture. Cataract surgery. Arthroscopy, endoscopy, laparoscopy. Organ biopsies. Dental extraction. Hernia repair. Intramuscular and paravertebral injections. Open pelvic, abdominal and thoracic surgery. Brain surgery. Major orthopaedic and trauma surgery. Vascular surgery. | B:257 NB:606 |
B:LMWH NB: NOAC |
30 |
| Kim, T. H.2015 [29] | Retrospective | AF | Not specified | B:1053 NB:4274 |
B:UFH NB: interrupt warfarin |
30 |
| Steinberg BA, et al.2015 [7] | Prospective | AF | Not specified | B:514 NB:1766 |
B:LMWH and UFH NB: interrupt warfarin & NOAC |
730 |
| Douketis JD, et al.2015 [8] | Randomized trial | AF | Not specified | B:895 NB:918 |
B:LMWH NB: interrupt warfarin |
30 |
| Douketis JD, et al.2015 [30] | Randomized trial | AF | day surgery/procedure, pacemaker/ICD,PCI, dental procedure, diagnostic procedure, other | B:800 NB:3306 |
B:LMWH and UFH NB: interrupt warfarin & NOAC |
30 |
| Dewilde WJM, et al.2015 [31] | Randomized trial | Not specified | PCI | B:322 NB:241 |
B:LMWH and UFH NB: continue warfarin |
365 |