Table 1.
Demographic characteristics of AD patients at baseline visit
| CT + H (N = 243) |
CT (N = 101) |
Total (N = 344) |
|
|---|---|---|---|
| Male sex — n (%) | 135 (55.55) | 57 (56.43) | 192 (55.81) |
| Age—yr., mean ± SD | 69.61 ± 8.92 | 67.50 ± 10.65 | 68.99 ± 9.49 |
| Education—yr., mean ± SD | 11.05 ± 5.63* | 9.60 ± 5.65 | 10.62 ± 5.66 |
| MMSE score— mean ± SD | 19.01 ± 6.37* | 20.47 ± 5.07 | 19.44 ± 6.05 |
| Mild — n | 121 | 56 | 177 |
| moderate — n | 93 | 44 | 137 |
| severe — n | 29 | 1 | 30 |
| ADL score—mean ± SD | 22.98 ± 9.13 | 21.28 ± 6.56 | 22.54 ± 8.56 |
| BMI—kg/m2, mean ± SD | 22.36 ± 3.79 | 22.73 ± 3.04 | 22.48 ± 3.57 |
| Smoke — n (%) | 37 (15.22) | 10 (9.90) | 47 (13.66) |
| Diabetes — n (%) | 19 (7.81)** | 0 (0) | 19 (5.52) |
| Hypertension — n (%) | 62 (25.51)*** | 6 (5.94) | 68 (19.76) |
| Donepezil — n (%) | 202 (82.13)*** | 98 (97.02) | 300 (87.21) |
| Memantine — n (%) | 64 (26.33)* | 14 (13.86) | 78 (22.67) |
| Both Donepezil and Memantine | 58 (23.86)* | 12 (11.88) | 70 (20.34) |
CT + H, conventional therapy with herbal granule; CT, conventional therapy alone; MMSE, mini-mental state examination; ADL, activities of daily living; BMI, body mass index. The activities of daily living (ADL) contain 14 items, which cover 8 items of Lawton instrumental ADL scale and 6 items of Katz ADL scale (score 1–4), the range is 14 to 56, and higher scores indicate worse function. Some differences were observed in education, MMSE, diabetes history, hypertension history, donepezil use, memantine use and both donepezil and memantine
* P < 0.05, ** <0.01, *** <0.001