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. 2017 Jun 30;31(12):2702–2708. doi: 10.1038/leu.2017.172

Figure 1.

Figure 1

Xenotransplantation of MDS BM MNCs. (a) Schematic representation of intrabone injection in NSG/NSG-S mice with or without MSCs. (b) hCD45+ engraftment in total mouse BM at the time of killing from NSG and NSG-S mice injected with patient MNCs (patients n=11; NSG mice n=20; NSG-S mice n=17). hCD45 ⩾0.01% in total mouse BM was considered as successful human cell engraftment. (c) hCD45+ engraftment in total mouse BM at the time of killing from NSG and NSG-S mice injected with patient MNCs±MSCs (autologous/allogeneic), (patients n=5 (MDS 36, 37, 38, 39 and 49)); MNCs alone NSG mice n=10; MNCs+MSCs NSG mice n=10; MNC alone NSG-S mice n=9; MNCs+MSCs NSG-S mice n=9).