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. 2017 Jun 30;31(12):2702–2708. doi: 10.1038/leu.2017.172

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Copyright © 2017 The Author(s)

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Sequencing and single-nucleotide polymorphism (SNP) karyotyping of in vitro MDS samples. (a) Mutational analysis of day 0 BM total nucleated cells or CD34⁺ cells and hCD45⁺ cells retrieved after LTC (MSCs and/or MS5; patients n=6; ‘-’ not available). (b) SNP karyotyping showing the maintenance of MDS48 clonality between pre- and post-culture. Presence of a trisomy-8 subclone (see red arrow) in both day 0 and post culture on MS-5.