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Inhibition of Wnt/β-catenin signaling blocks MMP-9 production. Human primary AEC cultured under submerged or ALI conditions were treated with FH535 or IWP2 to block respectively the β-catenin/TCF/LEF complex or Wnt secretion. AEC were then stimulated with TGF-β and/or poly(I:C) for 24 h before analysis of MMP-9 release by ELISA. Data are derived from 4 independent experiments and statistical significances were determined with a one-way ANOVA followed by a Tukey’s post-hoc test
