Table 3. Multivariate Cox regression analysis of serum THBS2 expression and HCC patients’ survival.
|
Disease-free survival |
Overall survival |
|||||
|---|---|---|---|---|---|---|
| Variable | HR | 95% CI | P value | HR | 95% CI | P value |
|
Age (years) | ||||||
| ⩾60 vs <60 | 1.684 | 0.740–3.829 | 0.214 | 2.395 | 1.015–5.647 | 0.046 |
|
Gender | ||||||
| Male vs female | 0.517 | 0.183–1.466 | 0.215 | 0.556 | 0.183–1.690 | 0.301 |
|
Tumour size (cm) | ||||||
| ⩾5 vs <5 | 0.934 | 0.406–2.149 | 0.873 | 1.048 | 0.457–2.405 | 0.912 |
|
Microvascular invasion | ||||||
| Positive vs Negative | 4.015 | 1.372–11.746 | 0.011 | 7.896 | 2.235–27.886 | 0.001 |
|
TNM stage | ||||||
| III+IV vs I+II | 2.168 | 0.883–5.324 | 0.092 | 3.134 | 1.198–8.202 | 0.020 |
|
AFP (ng ml−1) | ||||||
| ⩾20 vs <20 | 1.450 | 0.589–3.567 | 0.419 | 1.783 | 0.734–4.334 | 0.202 |
|
THBS2 (ng ml−1)a | ||||||
| ⩾36.9 vs <36.9 | 2.690 | 1.203–6.012 | 0.016 | 2.070 | 0.896–4.779 | 0.088 |
Abbreviations: AFP=alpha-fetoprotein; CI=confidence interval; HR=hazard ratio. Statistically significant values are in bold type.
a
For THBS2, median values were used as the cut-off point to demarcate high and low expression groups.