Table 2. Univariate and multivariate Cox proportional hazard ratios for metabolites and metabolite ratios and prostate cancer recurrence following radical prostatectomy.
|
Univariate analysis |
Multivariate analysis |
Multivariate analysis |
||||
|---|---|---|---|---|---|---|
|
Spermine model |
tChoCre/Spm model |
|||||
| Variable | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Spermine (log2) | 0.63 (0.50–0.80) | <0.001 | 0.72 (0.55–0.94) | 0.016 | ||
| tChoCre/Spm (log2) | 1.55 (1.23–1.96) | <0.001 | 1.43 (1.08–1.91) | 0.014 | ||
| Citrate (log2) | 0.67 (0.51–0.86) | 0.002 | ||||
| tChoCre/Cit (log2) | 1.38 (1.11–1.71) | 0.004 | ||||
| Choline (log2) | 1.59 (1.05–2.39) | 0.028 | ||||
| Creatine (log2) | 0.75 (0.48–1.19) | 0.22 | ||||
| Age (continuous) | 1.02 (0.97–1.07) | 0.42 | ||||
| Preoperative PSA | 1.02 (0.98–1.07) | 0.329 | ||||
| Grade group (RP) | ||||||
| 1 | Reference | Reference | Reference | |||
| 2 | 0.38 (0.14–1.05) | 0.062 | 0.55 (0.18–1.70) | 0.30 | 0.53 (0.17–1.65) | 0.27 |
| 3 | 0.92 (0.34–2.51) | 0.87 | 0.83 (0.28–2.44) | 0.74 | 0.73 (0.24–2.23) | 0.59 |
| 4 | 2.12 (0.67–6.71) | 0.20 | 2.73 (0.81–9.18) | 0.11 | 2.58 (0.76–8.72) | 0.13 |
| 5 | 3.01 (0.95–9.56) | 0.061 | 2.04 (0.61–6.85) | 0.25 | 2.00 (0.60–6.71) | 0.26 |
| EPE | 4.65 (2.61–8.27) | <0.001 | 3.03 (1.54–5.96) | 0.0013 | 2.98 (1.51–5.89) | 0.0017 |
| SVI | 3.39 (1.76–6.54) | <0.001 | 1.02 (0.46–2.72) | 0.95 | 1.06 (0.49–2.31) | 0.87 |
| PSM | 1.67 (0.95–2.94) | 0.074 | ||||
Abbreviations: CI=confidence interval; EPE=extraprostatic extension; HR=hazard ratio; PSA=prostate-specific antigen; PSM=positive surgical margins; RP=radical prostatectomy; SVI=seminal vesicle invasion; tChoCre/Cit=(total-choline+creatine)/citrate; tChoCre/Spm=(total-choline+creatine)/spermine.