Table 1. Examples of reports showing a role for caspase-8 and/or DR5 in apoptosis mediated by components of the UPR or the integrated stress response.

Mediator	Stimulus	Cell type	Reference
Caspase-8	Tunicamycin	HEK293, MCF7	Tomar et al. (2013), PMID 24021263
		bax^−/−bak^−/− BMK	Ullman et al. (2011), PMID 21576355
	Bortezomib/MG132	HEK293, MDAMB231, MCF7	Pan et al. (2001), PMID 21628531
Caspase-8, FADD	Bortezomib/MG132	Atg5+/+ and Atg5−/− MEFs, FADD+/+ and FADD−/− MEFs, KG-1	Young et al. (2012), PMID 22362782
		HeLa, H460, MEFs	Laussmann et al. (2011), PMID 21455219
	Tunicamycin, thapsigargin	CASP9−/− MEFs, bax/Bak−/− MEFs	Deegan et al. (2014), PMID 25470234
Caspase-8, RIPK1	Tunicamycin	MEFs and HEK293T	Estornes et al. (2014), PMID 25476903
DR5	Thapsigargin	HCT116, LNCaP, A2780S and DU145	Yamaguchi et al.,⁸ PMID 15322075
DR5, caspase-8	Thapsigargin, tunicamycin	MCF10A	Martín-Pérez et al.,⁹ PMID 24453000
	Thapsigargin	HCT116, SK-MES-1, KSM11, RPMI-8226	Lu et al.,² PMID 24994655
	CB-5083	HCT116	Anderson et al. (2015), PMID 26555175
DR5, DR4	Glucose deprivation Tunicamycin, thapsigargin	HCT116, HCT116 Bax, Bak (−/−), HeLa HCT116, MDA-MB231, H1703	Iurlaro et al. (2017), PMID 28242652 Dufour et al. (2017), PMID 28039489
DR4/TRAIL-R1	Tunicamycin, thapsigargin	A549	Li et al. (2015), PMID 25770212