Figure 3.

P53 activates a multitude of cellular effector processes. Model showing a selected cellular effector processes that can be activated by p53. Some, but not all, of the p53 target genes that are critical for the execution of these processes are indicated. The challenge remains to understand of which of these processes are critical for tumour suppression in which setting; that is, cell of origin undergoing neoplastic transformation and nature of the oncogenic lesions driving their transformation