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. 2017 Nov 10;25(1):133–143. doi: 10.1038/cdd.2017.174

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Mechanisms of context-specific regulation of p53 target genes. (a) ΔNp63α-mediated recruitment of H2A.Z may serve to license some p53 enhancers in epithelial cells.¹⁰¹ (b) Methylation of the SFN promoter blocks transactivation by p53 in some cell types.¹¹³ (c) E2A cooperates with p53 to promote transcription and processing of CDKN1A.¹¹⁹ (d) Insulation by CTCF chromatin boundaries in specific cell types could block transactivation of some p53 target genes. (e) Long-range chromatin interactions contribute to activation of some p53 target genes by bringing p53 enhancers into proximity with target gene promoters. (f) An intragenic chromatin boundary marked by CTCF binding prevents transcription of full-length BBC3/PUMA under basal conditions.¹²² CPE, core promoter element; Me, DNA methylation; PIC, preinitiation complex; p53RE, p53 response element; RNAPII, RNA polymerase II.