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. 2017 Oct 27;25(1):144–153. doi: 10.1038/cdd.2017.178

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TAp73 is a crucial transcriptional regulator of multiciliogenesis. Scheme of cilium (left) and direct target genes of TAp73 in ciliogenesis (right). Genes were identified by RNA-seq analysis of WT versis TAp73KO airway cultures during MCC differentiation, combined with ChIP-seq analysis in TAp73α/β-expressing Saos-2 cells. In addition to central ciliogenic transcription factors and regulatory miR34bc, key structural and functional ciliary genes of every category including eight human PCD-associated genes indicated in red are among them. Modified with permission from Nemajerova et al., 2016. IFT, intraflagellar transport; MTs, microtubules