Table 3.
ATS/CDC/IDSA guidelines for dosages of anti-tuberculosis drugs for the treatment of drug-susceptible tuberculous meningitis in children and adults
| Anti-tuberculosis drug | Daily dose in children | Daily dose in adults |
|---|---|---|
| Isoniazid | 10–15 mg per kg | 5 mg per kg (typically 300 mg) |
| Rifampin | 10–20 mg per kg | 10 mg per kg (typically 600 mg) |
| Ethambutol | 20 (15–25) mg per kg | Weight 40–55 kg: 800 mg |
| Weight 56–75 kg: 1200 mg | ||
| Weight 76–90 kg: 1600 mg | ||
| Pyrazinamide | 35 (30–40) mg per kg | Weight 40–55 kg: 1000 mg |
| Weight 56–75 kg: 1500 mg | ||
| Weight 76–90 kg: 2000 mg |
Adult dosing starting at age 15 years or weight > 40 kg in younger children. Source: [56]