Table 1.
Rate of Change in Insulin Secretion without Cytokine Exposurea
| experimental condition | low—high glucose stimulation (× 10−2) (normalized insulin content min−1) | high—low glucose shut- down (× 10−2) (normalized insulin content min−1) |
|---|---|---|
| Control | 0.86 | −0.71 |
| SNM, Diff | 0.84 | −0.42 |
| SNM, Conv | 1 | −2.71 |
| SμM, Conv | 3.15 | −3.36 |
a
The rate of change in insulin production was calculated based on the slopes of curves that were fitted on glucose—insulin kinetics graphs to describe the quickness of insulin being secreted as glucose concentration changes. Without subjection to cytokines, SμM-encapsulated mouse islets under convection (SμM, Conv) showed the fastest response following high glucose exposure, whereas SNM- and SμM-encapsulated mouse islets under convection (SNM, Conv & SμM, Conv) exhibited a similar rate of insulin cessation when glucose concentration returned to normal.