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. 2017 Dec 11;10:5863–5872. doi: 10.2147/OTT.S149361

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© 2017 Peng et al. This work is published and licensed by Dove Medical Press Limited

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The expression of UHRF2 in human cancers and ICC patients.

Notes: (A) Microarray data analysis of UHRF2 mRNA in gastric cancer, colon cancer, and hepatocellular carcinoma from the publicly available Oncomine database. (B) UHRF2 protein expression in randomly selected ICC tissues and their matched peritumor tissues by Western blot. (C) Relative expression of UHRF2 among tumor and peritumor tissues using qRT-PCR. (D) Positive UHRF2 was observed primarily in the cytoplasm. Representative UHRF2 and H<E staining are displayed. Scale bar =50 μm, magnification: 200×. (E) The density analysis revealed statistical significance of UHRF2 level of 100 cases of patients in TMA samples. *P<;0.05, ***P<;0.001.

Abbreviations: H<E, hematoxylin and eosin; ICC, intrahepatic cholangiocarcinoma; qRT-PCR, quantitative real-time polymerase chain reaction; TMA, tissue microarray; UHRF2, ubiquitin-like with PHD and ring finger domains 2; IHC, immunohistochemistry.