Table 2.
Univariate and multivariate analyses of factors associated with recurrence and survival
| Variable | Overall survival
|
Cumulative recurrence
|
||||
|---|---|---|---|---|---|---|
| Univariate
|
Multivariate
|
Univariate
|
Multivariate
|
|||
| P-value | HR (95% CI) | P-value | P-value | HR (95% CI) | P-value | |
| Age, years (≥53 vs <;53) | 0.529 | NA | 0.331 | NA | ||
| Gender (men vs women) | 0.836 | NA | 0.697 | NA | ||
| HBsAg (positive vs negative) | 0.659 | NA | 0.335 | NA | ||
| Child–Pugh score (A vs B) | 0.132 | NA | 0.078 | NA | ||
| Serum CA 19-9, ng/mL (≥37 vs <;37) | 0.483 | NA | 0.339 | NA | ||
| Serum ALT, U/L (≥75 vs <;75) | 0.585 | NA | 0.824 | NA | ||
| Serum AFP, ng/mL (≥20 vs <;20) | 0.259 | NA | 0.756 | NA | ||
| Cirrhosis (yes vs no) | 0.382 | NA | 0.587 | NA | ||
| Microvascular invasion (yes vs no) | 0.243 | NS | 0.134 | NS | ||
| Maximal tumor size (diameter, cm) (≥5 vs <;5) | 0.040 | NS | 0.007 | NS | ||
| Tumor number (multiple vs solitary) | 0.008 | NS | 0.002 | NS | ||
| Embolus (yes vs no) | 0.036 | NS | 0.032 | NS | ||
| Tumor differentiation (III/IV vs I/II) | 0.028 | NS | 0.033 | NS | ||
| Lymphatic metastasis (yes vs no) | 0.008 | 0.642 (0.418–0.986) | 0.043 | 0.002 | 0.559 (0.336–0.853) | 0.007 |
| UHRF2 density (<;50% vs ≥50%) | <;0.001 | 0.004 (0.001–0.234) | 0.008 | 0.042 | 0.013 (0.001–0.724) | 0.034 |
Abbreviations: ALT, alanine aminotransferase; AFP, α-fetoprotein; CA 19-9, carbohydrate antigen 19-9; HBsAg, hepatitis B surface antigen; HR, hazard ratio; NA, not adopted; NS, not significant; UHRF2, ubiquitin-like with PHD and ring finger domains 2.