Table 3.
Multivariate prognostic analysis of unmatched and matched populations
| Variables | Unmatched
|
Matched
|
||||||
|---|---|---|---|---|---|---|---|---|
| CSS
|
OS
|
CSS
|
OS
|
|||||
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Age (years) | ||||||||
| <50 | – | 1 | – | – | ||||
| ≥50 | – | – | 2.084 (1.800–2.413) | <0.001 | – | – | – | – |
| Race/ethnicity | ||||||||
| White | – | 1 | 1 | 1 | ||||
| Black | – | – | 1.317 (1.075–1.615) | 0.008 | 2.755 (1.485–5.111) | 0.001 | 2.357 (1.400–3.968) | 0.001 |
| Others | – | – | 0.812 (0.640–1.031) | 0.088 | 0.716 (0.169–3.034) | 0.650 | 0.834 (0.298–2.337) | 0.730 |
| Tumor grade | ||||||||
| G1 and 2 | 1 | 1 | 1 | 1 | ||||
| G3 and 4 | 1.382 (1.118–1.708) | 0.003 | 1.219 (1.054–1.411) | 0.008 | 1.793 (0.925–3.475) | 0.084 | 1.682 (0.999–2.834) | 0.050 |
| Tumor size (mm) | 1.053 (1.042–1.065) | <0.001 | 1.028 (1.020–1.035) | <0.001 | 1.046 (1.006–1.087) | 0.023 | 1.026 (0.998–1.055) | 0.073 |
| FIGO stage | ||||||||
| IB1 | 1 | 1 | – | – | ||||
| IIA1 | 2.063 (1.548–2.749) | <0.001 | 1.800 (1.449–2.236) | <0.001 | – | – | – | – |
| Nodal stage | ||||||||
| Negative | 1 | 1 | – | – | ||||
| Positive | 1.864 (1.494–2.325) | <0.001 | 1.375 (1.155–1.636) | <0.001 | – | – | – | – |
| Treatment | ||||||||
| Radiochemotherapy | 1 | 1 | – | – | ||||
| Hysterectomy | 0.693 (0.457–1.050) | 0.083 | 0.799 (0.568–1.124) | 0.198 | – | – | – | – |
Note: “–” indicates no data.
Abbreviations: CI, confidence interval; CSS, cancer-specific survival; G1, well differentiated; G2, moderately differentiated; G3, poorly differentiated; G4, undifferentiated; FIGO, International Federation of Gynecology and Obstetrics; HR, hazard ratio; OS, overall survival.