Table 4.

Parameter values used for scaling in module II

Parameter	Human Values	Direct Scaling		Allometric Scaling¶		Multi-Functional Scaling
	(70 kg)	Micro-human (70 mg)	Nano-human (70 ug)	Micro-human (70 mg)	Nano-human (70 ug)
Qsys (ml/day)†	9.4*106	9.4	9.4*10−3	259	1.0	30
Qgut (ml/day)†	0.10*Qsys	0.30*Qsys
Qliv (ml/day)†	0.05*Qsys	0.15*Qsys
Qkid (ml/day)†	0.19*Qsys	0.55*Qsys
QK,lum (ml/day)†	18*104	0.18	1.8*10−4	7.8	5.4*10−2	3.0 ± 0.04#
Agut (cm2)§	30*104	30*10−2	30*10−5	1.4*10−1 ++	7.7*10−4 ++	4.67
Akid (cm2)ˆ	6.1*104	6.1*10−2	6.1*10−6	11.6“	0.16“	4.67
Vgut,ap (ml)†	510	0.5*10−3	0.5*10−6	4.6*10−3	0.7*10−5	0.1
Vgut,bas (ml)†	510	0.5*10−3	0.5*10−6	4.6*10−3	0.7*10−5	0.3 ± 0.02#
Vliv (ml)†	1800	1.8*10−3	1.8*10−6	3.9*10−3	1.1*10−5	0.2 ± 0.03#
Vmix (ml)†	5300	5.3*10−3	5.3*10−6	5.3*10−3	5.3*10−6	0.4
Vkid, ap (ml)†	155	1.6*10−4	1.6*10−7	1.1*10−3	3.1*10−6	0.1
Vkid, bas (ml)†	155	1.6*10−4	1.6*10−7	1.1*10−3	3.1*10−6	0.8 ± 0.3#
Waste (ml)	QK,lum * t
Hepatocytes (number)¶	3*1011	3*105	3*102	8*105	2*103	5*105

Human volumes refer to whole organ volumes and total blood volume (V_mix); for all scaling approaches volumes refer to MPS media volumes.

References for human values:

^§Brown et al 1989²⁶

^†Valentin et al 2002⁷³

^¶Wikswo et al 2013¹⁹

^ˆScotcher et al 2016⁶¹

^“scaled using number of nephrons

⁺⁺Martin et al 1985 ⁷⁴

^#estimated using multi-functional scaling