Table 2. Summary of findings from other studies examining associations between SA virulence and specific genes, CCs.
| References | Patients | Genetic analysis | Multiple testing correction | Findings |
|---|---|---|---|---|
| Peacock et al. [3] | 179 S. aureus nasal carriers vs 155 S. aureus invasive disease | PCR | None | Invasive S. aureus associated to 7 genes: fnbA, cna, sdrE, sej, eta, hlg, icaA. |
| Feil et al. [5] | 179 S. aureus nasal carriers vs 61 invasive CA S. aureus infections vs 94 hospital acquired invasive S. aureus infections | MLST | None | No association between CC and invasiveness of infection. |
| Fowler et al. [4] | 118 S. aureus nasal carriers vs 104 uncomplicated SAB and STI* vs 157 IE and ostitis | MLST+PFGE+PCR | None | CC5 associated to invasiveness in MSSA and CC30 associated to invasiveness in MRSA. |
| Lalani et al. [9] | 65 MRSA SAB vs 24 MRSA IE | PFGE+PCR for 33 virulence genes | FDR (20 %) | USA300 (CC8) MRSA bacteraemia associated to intravenous drug use and right sided IE. Persistent MRSA SAB associated to seg gene. Non-persistent MRSA SAB associated to pvl gene. |
| Nienaber et al. [7] | 114 S. aureus STI* vs 114 IE | MLST+PCR | FDR (10 %) | IE associated to CC30 and 5 genes: cna, map/eap, tst, sei, sdrC. |
| Tristan et al. [10] | 81 MSSA SAB vs 89 MSSA IE | MLST+DNA microarray 185 genes | None | No association between CC or virulence genes and IE. Intravenous drug use associated to CC8. |
| Rasmussen et al. [6] | 46 S. aureus nasal carriers vs 55 SAB vs 33 IE | MLST+DNA microarray 170 genes | None | CC30 associated to nasal carriage. Invasive S. aureus associated to 4 genes: cap5, sasG, fnbB, LukD/LukE. |
| Nethercott et al. [8] | 24 S. aureus STI* vs 49 SAB vs 24 IE | MLST+PCR microarray 185 genes | None | PERMANOVA showed CC12+CC20 associated to IE. IE associated to 8 genes: ssl03, ss17-set1, ssl8-set12, ssl08, ssl9-set5, setB3, fib, lukY-var1. |
| Bouchiat et al. [11] | 54 CA-SAB vs 72 native valve CA-IE | Multiplex PCR+microarray+DAPC | Bonferroni | CC15 associated to IE. Univariate genetic markers with no association to IE. Combination of 8 specific genetic markers showed subtle association to IE. No phenotypic differences. |
*STI, Skin and soft tissue infection.