Table 3.

Summary of effect sizes (Cohen’s d) and P values for seven novel SNPs with CYP2A6 phenotypes (enzyme activity, protein levels, and mRNA expression) in White liver donors

SNP rs ID	Genotype groups compared	CYP2A6 enzyme activity (nmol/min/mg), N=327		CYP2A6 protein levels (pmol/mg), N=320		CYP2A6 mRNA expression (FPKM values), N=265
		Effect size	P value	Effect size	P value	Effect size	P value
rs57837628	AA vs. AG	0.53	0.002	0.57	0.0008	0.38	0.20
	AA vs. GG	0.67	0.0001	0.74	<0.0001	0.27	0.75
rs7260629	TT vs. TG	0.44	0.23	0.46	0.15	0.07	>0.99
	TT vs. GG	0.65	0.01	0.68	0.007	0.17	>0.99
rs7259706	CC vs. CT	0.06	0.31	0.04	0.49	0.45	0.17
	CC vs. TT	0.30	0.02	0.28	0.02	0.41	0.19
rs150298687	TT vs. TC	0.48	0.02	0.48	0.02	0.44	0.27
	TT vs. CC	0.60	0.004	0.62	0.002	0.32	0.80
rs56113850	TT vs. TC	0.40	0.03	0.48	0.009	0.44	0.12
	TT vs. CC	0.59	0.001	0.66	0.0003	0.32	0.56
rs28399453	GG vs. GA & AA	0.39	0.04	0.28	0.11	0.17	0.91
rs8192733	GG vs. GC	0.44	0.001	0.49	0.002	0.25	>0.99
	GG vs. CC	0.65	<0.0001	0.80	<0.0001	0.21	>0.99