Table 5.

Five-SNP phased diplotypes predicted in treatment-seeking smokers in PNAT trial

Diplotype Group #	Full Diplotype	N in PNAT	CYP2A6 activity (nicotine metabolite ratio, NMR), mean of diplotype group	Corresponding liver bank diplotype group
Reference	G T T T A / G T T T A	41	0.3	Reference Group
1	G C C G G / G C C G G	110	0.55	1
2	G T T T A / G C C G G	123	0.40	2
3	G T T G A / G C C G G	43	0.46	3
4	G C C G A / G C C G G	55	0.55	4
5	G T T T A / G T T G A	20	0.38	5
6	G C C G G / A C C G G	38	0.49	6
7	G T T T A / A C C G G	29	0.42	7
8	G T T T A / G C C G A	30	0.43	8
9	G T T G A / G C C G A	8	0.42	9
10	G T T G A / A C C G G	8	0.54	10
11	G C C G A / A C C G G	10	0.54	11
12	G T T T A / G C C T G	5	0.48	13
13	A C C G G / A C C G G	3	0.45	14
14	G C C G A / G C C G A	11	0.41	15
15	G T C G G / G C C G G	2	0.21	22
16	G C T G G / G C C G G	23	0.54	N/A
17	G T T T A / G C T G G	13	0.45	N/A
18	G C C G G / A C T G G	12	0.46	N/A
19	G T T G G / G C C G G	11	0.46	N/A
20	G C C T G / G C C G G	10	0.60	N/A
21	G C C G A / A C T G G	6	0.51	N/A
22	G C T G G / G C C G A	5	0.54	N/A
23	G C T T G / G C C G G	4	0.67	N/A
24	G T T T A / G C T G A	4	0.45	N/A
25	G T T G A / G T T G G	2	0.35	N/A
26	G T T T A / G T T G G	2	0.33	N/A
27	G C C T G / A C C G G	1	0.69	N/A
28	G T T G G / A C C G G	1	0.35	N/A
29	A C T G G / A C T G G	1	0.46	N/A
30	G T T T A / A C T G G	1	0.53	N/A
31	G C C T G / G C C G A	1	0.67	N/A
32	G C C T G / G C C T G	1	0.30	N/A
33	G C T T G / G C C T G	1	0.48	N/A
34	G C T G A / G C T G A	1	0.61	N/A
35	G C T G G / G C T G G	1	0.54	N/A
36	G T T G A / G C T G G	1	0.43	N/A
37	G T T G G / G C T G G	1	0.33	N/A
38	G T T T A / G C T T G	1	0.36	N/A
39	G T T T A / G T C G A	1	0.22	N/A

^a. Full reference diplotype is bolded