| Chronic idiopathic anal fissure |
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| Sexually transmitted disease: herpes, syphilis, gonorrhea, granuloma inguinale, chancroid, chlamydia, candidiasis |
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| Other infections: tuberculosis, Streptococcus spp. |
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| Ulcerative colitis or Crohn's disease |
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| Malignancy: squamous cell carcinoma, adenocarcinoma, melanoma or other skin tumors, Paget's disease, histiocytosis, anal metastasis, leukemia |
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| Dermatosis: anal eczema, Lichen sclerosus, Lichen planus, Behçet disease |
|
| Chemotherapy |
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| Idiopathic anogenital ulceration in HIV |
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| Trauma |
