Table 1.

Parameter values used in this study to model low and high-affinity ribosome-targeting antibiotics. These values are chosen to be within the range of the literature values collated in [8]. The universal parameters are κ_t = 6.1 × 10⁻² µM h⁻¹, r_min = 19.3 µM and r_max = 65.8 µM [8, 20]. Except where stated otherwise, we have assumed an antibiotic-free growth rate λ₀ of 1 h⁻¹.

Parameter	Value for low-affinity antibiotic	Value for high-affinity antibiotic
Pin	2000 h−1	1 h−1
Pout	100 h−1	0.01 h−1
kon	1000 μM−1 h−1	1000 μM−1 h−1
koff	105 h−1	10 h−1
${\lambda }_0^{*}=2\sqrt{P_{\text{out}}{\kappa }_t{k}_{\text{off}}/k_{\text{on}}}$	49.4 h−1	0.00493 h−1
$\text{I}{\text{C}}_{50}^{*}={\lambda }_0^{*}(r_{\max }-r_{\min })/(2P_{\text{in}})$	0.574 μM	0.115 μM
Predicted IC50 (from equation (8))	1.43 μM	11.64 μM