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. 2017 Dec 14;12(12):e0189315. doi: 10.1371/journal.pone.0189315

Fig 1. Female mice with DCM show accelerated declines in systolic function and increased lung water retention when compared with male mice with DCM.

Fig 1

Age- related changes in ejection fraction (EF%) in female (A) and in male mice(D) fractional shortening (FS%) in female (B) and in male mice (E) LW/BW% in female (C) and in male (F) mice with and without DCM. Figs 1D, 1E and 1F were reproduced from our previously published data [19]. Female or male with DCM are indicated by closed symbols, female or male without DCM by open symbols. The number of animals per group at each time point is shown. Age dependent changes in both sexes were analyzed by two-way ANOVA. At 13 weeks of age, changes in EF% (G) FS% (H) and LW/BW% (I) in female and male mice with or without DCM. DCM-F (DCM female, red), DCM-M (DCM male, black), dotted red (female) and black (male) line represent mean baseline levels in mice without DCM. The number of DCM mice is indicated. Differences among groups at 13 weeks were analyzed by one-way ANOVA. ***P<0.001 (DCM female vs DCM male). +++P<0.001, and +P<0.05 (DCM vs. WT mice).