Fig 3. Sex differences in the activation of RAAS axis in mice with DCM.

Plasma levels of (A) active renin (B) angiotensin II and (C) aldosterone in female and male DCM and WT control mice, at 13 weeks, determined by ELISA. (D) Aldosterone to active plasma renin ratio in DCM and WT mice. The number of DCM mice is indicated. Female and male base line levels were indicated by red and black dotted line respectively (WT mice, n = 6–8 per group). Plasma active renin levels (arbitrary units) in female (E) and in male (H), angiotensin II plasma levels in female (F) and in male (I), Aldosterone plasma levels in female (G) and in male, DCM and WT control mice (J). The number of animals per group at each time point is shown. Female and male mice with DCM (closed symbol) female and male WT mice (open symbol). Systolic blood pressure (K) and diastolic blood pressure (L) in female and male, DCM and WT mice. The number of DCM mice is indicated, WT mice, n = 4–8 per group. ***P<0.001, **P<0.01, *P<0.05 (DCM female vs. DCM male). ⁺⁺⁺P<0.001, ⁺⁺P<0.01, ⁺P<0.05 (DCM vs WT).