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. 2017 Dec 14;12(12):e0189102. doi: 10.1371/journal.pone.0189102

Fig 5. Inhibition of the TAK1-NFkB axis phenocopies FLT3-L deprivation.

Fig 5

A) Percentage of Annexin V-positive CB MLL-AF9 cells after 24 hours incubation with DMSO or AZ-TAK1 inhibitor or IKK VII in different concentrations (technical triplicate ± s.d of 3 independent experiments). B) Growth curves for immortalized CB MLL-AF9 MS5 co-cultures treated with different concentrations of AZ-TAK1 inhibitor (arrows indicate treatments; a representative of three independent experiments is shown). C) Microscope images of immortalized CB MLLAF9 MS5 co-cultures. Cobblestone formation was reduced upon TAK1 inhibitor treatment. D) qPCR on CB MLL-AF9 cells after 24 hours treatment with 5z-7-oxoezeanol or IKK VII inhibitor (E).