Table 7. Parameters of the optimized formulations (n = 3).
| F | P407 (%) |
P188 (%) | HPMC (%) |
pH | Clarity | Tgel (°C) |
Gel strength (sec) |
Mucoadhesive strength (dyn/cm2) |
|---|---|---|---|---|---|---|---|---|
| S1 | 21.1 | 4.0 | 0.1 | 6.3 | ++ | 30.6±0.2 | 29±1.7 | 4560±106 |
| S2 | 20.2 | 1.5 | 0.2 | 6.4 | ++ | 30.8±0.2 | 35±2.4 | 3885±68 |
| S3 | 20.5 | 3.3 | 0.3 | 6.5 | ++ | 30.8±0.1 | 37±2.5 | 4450±46 |
| S4 | 19.7 | 1.3 | 0.5 | 6.4 | ++ | 29.7±0.2 | 38±0.9 | 4555±82 |
| S5 | 19.9 | 2.4 | 0.6 | 6.4 | ++ | 30.2±0.1 | 46±1.2 | 5330±53 |
| S6 | 19.6 | 1.5 | 0.8 | 6.3 | ++ | 31.0±0.3 | 58±1.8 | 6780±72 |
| S7 | 19.6 | 1.6 | 0.9 | 6.5 | ++ | 31.3±0.2 | 59±1.2 | 8945±115 |
| S8 | 19.4 | 1.1 | 1.0 | 6.5 | ++ | 29.6±0.3 | 67±2.2 | 10935±62 |
Note: turbid: +, clear: ++, very clear (glassy): +++