Fig 3. Low fat diet restores levels of IGF-1, myoglobin, activity, and serum lipids in Cpt1b^m-/- mice.

(A) Serum levels of IGF-1 are plotted for control (white circles) and Cpt1b^m-/- (black squares) mice for each of the diets tested at 4–6 months (N = 10 animals per genotype for low fat diet and N = 14 animals per genotype for chow diet). (B) Serum myoglobin levels in animals fed either low fat or chow diets (N = 9 animals per genotype for low fat diet; and N = 10 control and 8 Cpt1b^m-/- for chow diet). (C-D) Activity variation is plotted for control (white circles) and Cpt1b^m-/- (black squares) mice fed chow diet (C) (N = 9 animals per genotype) or low fat diet (D) (N = 12 animals per genotype). Grey sections indicate periods of darkness, while white sections indicate periods of light. (E-F) Serum levels of NEFA (E) and serum levels of 3-hydroxybutyrate (F) in control (white) and Cpt1b^m-/- (black) mice fed chow or low fat diet (N = 9 for control animals and N = 10 for Cpt1b^m-/- animals). Asterisks indicate significance with P ≤ 0.05.