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. Author manuscript; available in PMC: 2018 Nov 28.
Published in final edited form as: Chem Commun (Camb). 2017 Nov 28;53(95):12814–12817. doi: 10.1039/c7cc07582k

Figure 1.

Figure 1

Structure of NAPE-PLD and structural details discussed in the text. Chain A and chain B are illustrated in light blue and beige, respectively. The polar head-group (red oxygens and orange phosphorus) of NAPE coordinates the diatomic zinc center (black spheres). The sn-1 and sn-2 acyl chains (grey carbons) interact with bile acid molecules (yellow carbons) that occupy a recognition pocket present at the membrane interface. The N-acyl chain of NAPE (dark blue carbons) may be accommodated within the hydrophobic pocket (blue) found in close proximity of the zinc center. Glutamine 320 (magenta) may form polar interactions with the N-acyl chain of NAPE. Also shown in figure are glutamine 158 and tyrosine 159 (green), which are important in dimer formation.