. Author manuscript; available in PMC: 2017 Dec 14.

Published in final edited form as: Neurotoxicology. 2016 Aug 25;60:171–177. doi: 10.1016/j.neuro.2016.08.013

Table 1.

Effects of mutations within the two pyrethroid receptor sites on the action of DMT and PMT. Symbols ↓, ↑, and ≈indicate decrease, increase, or insignificant change of the ligand potency, respectively.

PyR1					PyR2
Mutant	Ref.^a	DMT	PMT	DDT	Mutant	Ref.^a	DMT	PMT	DDT
L^22k7F/I	1	↓/↓	≈/↑	≈	I^1k7A	3	↓	↓
M^2k11T	1	↓	↓	↑	V^1k11A	3,6	↓	↓	↓
					S^11o2A	5	↓	↓
L^2o6I	1	↓	↓	↓	L^1o6I/A	3,5,6	↑/≈	≈/↑	↑/
T^22o10I	1	↓	↓	↓	I^1o10C	3,6	↓	↓	≈
L^22o13F	1	↓	≈	↓	T^1o13W/A	3,6	≈/	≈/	/≈
C^22o14A	1	↓	↑	↓
V²ⁱ¹⁸G	3	↓	↓		L¹ⁱ¹⁸G	3	↓	↓
F²ⁱ²²S^b	5,6	↓	↓	↓	I¹¹ⁱ²²A	5,6	↓	↓	↑
L²²ⁱ²⁵A	5,6	↓	↓	↓	I¹¹ⁱ²⁵A	5,6	≈	≈	≈
L²²ⁱ²⁶A	5	↓	↓
					S¹ⁱ²⁹A	5	↓	↓
I³ⁱ¹²A	2,6	↑	↑	↓	V²²ⁱ¹²A/L	5,6	≈/↑	↑/↑	≈/
F³³ⁱ¹³C	3,6	↓	↓	↓	I²²ⁱ¹³M	3,6	≈	↓	↓
S³³ⁱ¹⁵A	2	≈	≈		N²ⁱ¹⁵S	5	↓	↓
F³ⁱ¹⁶A	2,6	↓	↓	↓	L²²ⁱ¹⁶F/S	3,6	↓/↓	↓/↓	↓/
F³³ⁱ¹⁷I	4	↓	↓
N³ⁱ²⁰A	2	↓	↓		N²ⁱ²⁰A	5	≈	≈

References: 1, (Usherwood et al., 2007); 2 (Du et al., 2009); 3 (Du et al., 2013) and references therein; 4 (Tan et al., 2005); 5, (Du et al., 2015); 6, (Du et al., 2016).

F²ⁱ²² contributes to both PyR1 and PyR2.