Figure 1.

Gut microbiome as a determinant of human health and response to therapeutic intervention. Gut microbiome plays an important role in an individual’s response to interventions raging from dietary and lifestyle changes to medications and surgical interventions; hence in addition to host genetics it is important to consider the role of gut microbiome when selecting appropriate therapy. Gut microbiome unlike host genes represents a modifiable factor that can be targeted by probiotics, prebiotics, diet as well as community replacement approaches such as fecal microbiota transplantation.