Figure 6.

RP444 treatment does not affect in vivo wound closure. Mice were wounded and treated with vehicle (PBS) or RP444 (2, 64, or 640 μg/mL) every 6 hours for 24 hours. Corneal wound areas were assessed by fluorescein staining every 6 hours. The percentage of wound remaining open was determined by comparison to the original wound area. Data represent mean ± SE and were analyzed with 2-way repeated measures ANOVA and Bonferroni's correction for multiple comparisons. *P < 0.05; statistically significant difference between vehicle and RP444 640 μg/mL treatment; n = 7–10 mice/group.