Figure 7.

RP444 significantly reduced ocular disease in a murine P. aeruginosa keratitis model. Data are mean clinical scores ± SE from two independent experiments 5 days post infection with n = 9, 5, 9, and 10 mice for 0, 2, 64, and 640 μg/mL groups, respectively. **P < 0.01 and ***P < 0.001; statistically significant difference among control and RP444 treated. The right side of the figure shows representative photographs of the treated infected right eyes compared to the uninfected left eye, illustrating a reduction in pathology (opacity) with RP444 treatment.