Table 2.
Fecal genera predict MRS-derived brain metabolites.a
| Dependent Variable | Step | Variable Entered | No. of variables included | Partial R2 | Model R2 | C(p) | F-value | P-value |
|---|---|---|---|---|---|---|---|---|
| myo-Inositol (mI)b | 1 | Bacteroides | 1 | 0.373 | 0.373 | −9.145 | 12.51 | 0.002 |
| 2 | Clostridium XIVb | 2 | 0.134 | 0.507 | −9.245 | 10.28 | 0.001 | |
| N-acetylaspartate (NAA)c | 1 | Ruminococcus | 1 | 0.367 | 0.367 | 9.530 | 12.17 | 0.002 |
| 2 | Butyricimonas | 2 | 0.160 | 0.527 | 4.331 | 11.13 | 0.001 | |
| Creatine + Phosphocreatine (Cr+PCr)d | 1 | Bacteroides | 1 | 0.261 | 0.261 | 22.47 | 7.424 | 0.013 |
Note.
a
Fecal microbiota (independent variable) presented as a relative abundance, MRS-derived neurometabolite (dependent variable) presented in parts per million, diet and other candidate genera did not meet criterion for inclusion in the model, N = 23.
b
Final model equation predicting brain mI, presented with unstandardized coefficients: Y = 7.180 + 0.039x1 + 0.127x2.
c
Final model equation predicting brain NAA, presented with unstandardized coefficients: Y = 4.997 – 0.160x1 + 0.155x2.
d
Final model equation predicting brain Cr+PCr, presented with unstandardized coefficients: Y = 3.778 + 0.010x1.