Table 1.
Results of PLAG1 Immunohistochemistry and FISH in salivary gland neoplasms.
|
PLAG1 rearrangements by FISHa |
PLAG1 IHCa |
Percentage of tumor cells positive for PLAG1 (mean ± SEM) |
PLAG1 intensity in positive cases (N) |
|||
|---|---|---|---|---|---|---|
| Weak | Moderate | Strong | ||||
| Pleomorphic adenoma (PA) | 5/15 (33%) | 22/23 (96%) | 50±4% | 5 | 4 | 11 |
| Carcinoma ex pleomorphic adenoma (CA ex-PA) | 10/12 (83%) | 9/15 (60%) | 36±7% | 1 | 5 | 3 |
| De novo myoepithelial carcinoma | 0/6 (0%) | 7/10 (70%) | 65±10% | 1 | 1 | 5 |
| De novo salivary duct carcinoma | 0/3 (0%) | 0/6 (0%) | NA | NA | NA | NA |
| Basal cell adenocarcinoma | 0/2 (0%) | 2/4 (50%) | 16±9% | 1 | 1 | NA |
| Polymorphous adenocarcinoma | 0/6 (0%) | 0/8 | NA | NA | NA | NA |
| Epithelial-myoepithelial carcinoma | ND | 1/2 (50%) | 50% | NA | NA | 1 |
| Mucoepidermoid carcinoma | ND | 1/ 4 (25%) | 15% | NA | 1 | NA |
| Adenoid cystic carcinoma | ND | 0/5 | NA | NA | NA | NA |
| Acinic cell carcinoma | ND | 0/5 | NA | NA | NA | NA |
| Secretory carcinoma | ND | 0/1 | NA | NA | NA | NA |
a
Values are expressed as number of positive cases/total number of cases tested (% of positivity).
IHC: immunohistochemistry; FISH: fluorescence in situ hybridization, NA: not applicable, ND: not performed, SEM: standard error of mean N, number of cases tested.